The Pennsylvania Department of Health (DOH) provides guidance in 2020-PAHAN-541 for responding to signs and symptoms following COVID-19 vaccination in health-care personnel (HCP). Strategies are needed for health-care facilities to appropriately evaluate and manage post-vaccination signs and symptoms among health-care personnel (HCP) in order to minimize staffing disruptions and the transmission of infectious diseases, including COVID-19.

Key points in the advisory include:

1. Signs and symptoms – such as fever, fatigue, headache, chills, myalgia, and arthralgia – can typically occur following COVID-19 vaccination. They usually occur within the first three days of vaccination.
2. Presence of signs and symptoms consistent with SARS-CoV-2 infection that are not typical for post-vaccination signs and symptoms (i.e. cough, shortness of breath, rhinorrhea, sore throat, loss of taste or smell) should not be attributed to the COVID-19 vaccine.
3. Positive viral (nucleic acid or antigen) tests for SARS-CoV-2, if performed, should not be attributed to the COVID-19 vaccine since vaccination does not influence the results of these tests.

A figure is provided to outline the steps health-care facilities should take in response to HCP who develop symptoms within the three days following vaccination for COVID-19. If you have questions about this guidance, please contact DOH at 1-877-PA-HEALTH (1- 877-724-3258) or your local health department.