Not seeking re-election:
 Rep. Paul Schemel (R–Franklin) (State House of Representatives – D90)
 Rep. Rob Mercuri (R–Allegheny) (State House of Representatives – D28)
 Rep. Ryan Mackenzie (R–Lehigh) (State House of Representatives – D187)
 Rep. John Galloway (D–Bucks) (State House of Representatives – D140) – Elected as Magisterial District Judge in Falls Township
 Rep. Patty Kim (D–Dauphin) (State House of Representatives – D103)
 Rep. Jim Marshall (R–Beaver) (State House of Representatives – D14)
 Rep. Mark Rozzi (D–Berks) (State House of Representatives – D126)
 Rep. George Dunbar (R–Westmorland) (House of Representatives – D56)
 Sen. John DiSanto (R–Dauphin) (State Senate – D15)
 Sen. Mike Regan (R–Cumberland) (State Senate – D31)
 Rep. Donna Oberlander (R–Clarion) (State House of Representatives – D63)
 Sen. Jim Brewster (D–Allegheny) (State Senate – D45)

Members seeking different seats/offices:
 Rep. Patty Kim (D–Dauphin) (State House of Representatives – D103) – Running for State Senate – D15
 Rep. Rob Mercuri (R–Allegheny) (State House of Representatives – D28) – Running for U.S. House of Representatives – D17
 Rep. Ryan Mackenzie (R–Lehigh) (State House of Representatives – D187) – Running for U.S. House of Representatives – D7
 Rep. Ryan Bizzarro (D–Erie) (State House of Representatives – D3) – Running for State Treasurer
 Rep. Mark Rozzi (D–Berks) (State House of Representatives – D126) – Running for State Auditor General
 Rep. Jarred Solomon (D–Philadelphia) (State House of Representatives – D202) – Running for State Attorney General
 Rep. Malcom Kenyatta (D–Philadelphia) (State House of Representatives – D181) – Running for State Auditor General
 Rep. Craig Williams (R–Delaware) (State House of Representatives – D160) – Running for State Attorney General
 Rep. Dawn Keefer (R–York) (State House of Representatives – D92) – Running for State Senate – D31
 Rep. Nick Pisciottano (D–West Mifflin) (State House of Representatives – D38) Running for State Senate – D45