The Pennsylvania Department of Health (PA DOH) has released an advisory regarding a multi-country cluster of Hantavirus cases linked to an international cruise ship expedition. The outbreak has been connected to the Andes virus strain, which is notable because it is the only known hantavirus capable of limited person-to-person transmission under close, prolonged exposure conditions. As of May 11, 2026, nine cases and three deaths have been reported internationally. At this time, PA DOH reports no known Pennsylvania residents connected to the outbreak.

Hantavirus infections remain extremely rare in the United States and particularly in Pennsylvania, where only two cases have been reported since 2010. Most infections are associated with exposure to rodent urine, droppings, saliva, or nesting materials in enclosed or poorly ventilated areas.

Providers and organizations should be aware of symptoms consistent with Hantavirus Pulmonary Syndrome (HPS), including fever, fatigue, muscle aches, cough, and shortness of breath, particularly when there is a known history of rodent exposure or close contact with a symptomatic individual linked to the Andes virus strain. Early symptoms may resemble influenza or COVID-19.

The Department of Health is advising healthcare providers to immediately report suspected cases to local public health authorities or the PA Department of Health at 877-PA-HEALTH.

RCPA encourages members to review the PA-HAN advisory and fact sheet for additional clinical guidance, infection control recommendations, and environmental cleaning protocols related to rodent exposure and prevention.